Grants & Awards

Current

NIH-NGMS R01-1042312909A1 (Georg Gerber)
Bayesian Machine Learning Tools for Analyzing Microbiome Dynamics
Development of Machine Learning Methods and Software to analyze longitudinal microbiome data
Total $352,296, direct $215,943, indirect $136,353
Role:  Co-PI (12% effort)
09/01/2018 – 08/31/2023

NSF-MCB (1817342)      (Carey Nadell)
Viral micro-epidemics and evolutionary dynamics in bacterial biofilms
Development of mathematical models and microfluidics experiments to investigate ecological and evolutionary dynamics of bacteriophages and bacteria in spatially structured biofilms
Total $247,521, direct $171,159, indirect $76,362 (to Bucci)
Role:  Co-PI (10% effort)
09/01/2018 – 08/31/2021
UMass President Science and Technology Award (Vanni Bucci)
Pipeline for probiotics discovery, engineering and manufacturing
Development of genetically engineered probiotics for the treating drug-resistant Salmonella infections
Total $125,000, direct $125,000, indirect $0.0
Role:  PI
07/01/2017 – 12/31/2019
Vedanta Biosciences Sponsored Research Agreement    (Vanni Bucci)
Machine learning and bioinformatics of translational microbiome data
Development and applications of deep learning non-parametric statistical methods to mine clinical datasets for associations between microbiome and inflammatory phenotypes
Total $283,896, direct $162,573, indirect $121,323
Role:  PI (12%)
09/01/2019 – 06/31/2021
Massachusetts Department of Public Health  (Catherine Neto & Vanni Bucci)
Exploring the potential impacts of bioactive compounds from cranberries on colon and gut health (https://www.umassd.edu/feature-stories/2018/cranberry-research.html)
Total $100,000, direct $100,000, indirect $0.0
Role:  MPI
01/01/2019 – 12/31/2019
UMass Dartmouth  Multidisciplinary Seed Fund (Michael Sheriff & Vanni Bucci)
The role of the gut microbiome in mediating individual responses to predation risk
Studies aimed at identifying microbiome members and functions that protect from stress-induced behaviors such as those in response to predation or enemy fire
Total $31,560
Role:  MPI
01/01/2019 – 12/31/2019

Pending

NIH-NBIB           R01-EB027699  (Vanni Bucci)
Computational design of synthetic microbiomics to combat drug-resistant gram-negative pathogens
Application of Synthetic and Systems Biology approaches to develop engineered bacteriotherapeutic consortia to decolonize multi-drug resistant Klebsiella and Salmonella
Total $3,148,083.00, direct $2,122,257.0, indirect 1,025,826.00
Role:  PI (30% effort)
07/01/2020 – 06/30/2024

NIH-NIA             R01-AG060952 (John Haran & Vanni Bucci)
Tracking and predicting multi-drug resistant organisms in at-risk nursing home elders
Identification of microbiome and clinical predictors of colonization and infection in nursing-home elders
Total $4,145,410.00, direct $2,919,956.00, indirect $1,225,454.00
Role:  MPI (20% effort)
Note: resubmitting November 2019
07/01/2019 – 06/30/2024
DOD     GRANT12901455           (Vanni Bucci)
Mathematical modeling and synthetic biology to discover new ESBL-PE eradicating microbiome-based therapeutics
Discovery and testing of new wildtype and engineered bacteriotherapeutics to decolonize ESBL-producing E. coli
Total $1,466,938.00, direct $1,000,048.00, indirect $466,890.00
Role:  PI (20% effort)
09/01/2020  – 08/31/2023
NIH       1 R01 AG067483-01 (John Haran)
Understanding the “Microbiome-gut-brain axis” in Alzheimer’s disease and its Role in Cognitive Decline
Application of computational modeling and machine learning to determine intestinal bacteria mediating dementia and cognitive decline
Total $392,707, direct $263,429, indirect $129,277 (to Bucci)
Note: This grant was review on October 9th and scored below payline for Early Investigators
Role:  Co-PI (20% effort)
04/01/2020 – 03/31/2025
NIH       R01AI148401 (Beth McCormick and Vanni Bucci)
Innate Immune-Modulating Bacteria to Protect Against C. difficile Disease using Mathematical Model-Based Discovery and Optimization
Project goal is to use computational and mathematical modeling to determine bacteria combinations protecting from C. difficile infection via innate immune induction.
Total $4,145,985.00, direct $2,628,634, indirect $1,515,351
Role:  Co-PI (20% effort)
Note: resubmitting November 2019
09/01/2019 – 08/31/2024

Completed

NIH-NIAID (1R15AI112985) (Vanni Bucci)
Mathematical modeling from metagenomics – minimizing enteric infections risk
Development of biostatistical methods to predict combinations of gut bacteria protecting from C. difficile and VRE bacteremia.
Total $464,739, direct $334,449, indirect $130,290
Role:  PI (15% effort)
02/01/2015 – 06/31/2018
NSF-ABI (DBI-1458347) (Vanni Bucci)
ABI Innovation: A new computational framework for the prediction of microbiome dynamics
Development, testing and validation of mathematical modeling tools for inference and predictions of temporal dynamics of polymicrobial systems.
Total $491,682, direct $356,291, indirect $135,391
Role:  PI (15% effort)
09/01/2015 – 08/31/2019
Vedanta Biosciences Sponsored Award (Vanni Bucci)
Sponsored work to the UMass Dartmouth Microbial Informatics Core
Development, testing and validation of mathematical modeling tools for inference and predictions of temporal dynamics of polymicrobial systems
Total revenue $112,000
Role:  PI (10% effort)
02/01/2018 – 07/31/2019
Albert Charitable Trust Fund (Catherine Neto & Vanni Bucci)
Impact of bioactive compounds from cranberries on colon and gut health
Exploration of effect of cranberry polyphenols on gastrointestinal microbiota and host immunity
Total $150,000
Role:  MPI (0.1% effort – funds directed only to students and for buying consumables)
01/01/2018 – 12/31/2018
Massachusetts DPH  (Catherine Neto & Vanni Bucci)
Impact of bioactive compounds from cranberries on colon and gut health
Exploration of effect of cranberry polyphenols on gastrointestinal microbiota and host immunity (DPH Match to Albert Charitable Award, see above)
Total $100,000
Role:  MPI (0.1% effort – funds directed only to students and for buying consumables)
01/01/2018 – 12/31/2018
UMCCTS Life Sciences Moment Fund Award (John Haran & Vanni Bucci)
Gut microbiome modeling to predict Clostridium difficile colonization in hospitalized patients
Development of mathematical models to predict microbiome and C. difficile dynamics in emergency medicine patients
Total $50,000
Role:  MPI (funds directed to fellow and for buying server)
01/01/2017 – 06/30/2017
UMass Dartmouth  Multidisciplinary Seed Fund (Christopher Brigham)
Propane synthesis by engineered microbial consortia
Engineering communities of bacteria to produce prophane from different waste sources
Total $21,000
Role:  Co-PI (funds directed only to students and for buying consumables)
01/01/2017 – 06/30/2017
UMass Dartmouth  Multidisciplinary Seed Fund (Vanni Bucci)
Leveraging evolution to develop therapeutics against enteropathogenic E. coli
Experimental evolution experiment to investigate trade-offs between environmental adaptation and survival in the host in enteropathogenic E. coli
Total $33,000
Role:  PI (funds directed only to students and for buying consumables)
01/01/2016 – 06/30/2016
UMass Dartmouth  Multidisciplinary Seed Fund (Vanni Bucci)
Model reduction techniques for patient-specific data inference for gut microbiota dynamics
Development of new mathematical and numerical methods for fast approximation of inverse problem solution using radial basis methods
Total $31,000
Role:  PI (funds directed only to students and for buying consumables)
01/01/2014 – 06/30/2014
UMass Dartmouth  Multidisciplinary Seed Fund (Mark Silby)
Understanding microbial dynamics to improve biotechnological applications
Development of microbial genetic engineering techniques to build synthetic systems of interacting communities of soil microbes
Total $22,000
Role:  Co-PI (funds directed only to students and for buying consumables)
01/01/2014 – 06/30/2014
Sponsored Research Agreement Vedanta Biosciences (Vanni Bucci)
Mathematical modeling of the intestinal microbiome to determine anti-inflammatory microbial consortia
Analysis of time-series microbiome data from gnotobiotic mice inoculated with anti-inflammation-inducing microbial consortia
Total $15,000
Role:  PI (funds directed to purchasing High-Performance Computing Server)
01/01/2014 – 06/30/2014

Current Unfunded Projects

 

Microbiome and immunity interplay in TB-affected populations. This project is a collaboration with TBRU at Cornell University and aims understanding how the microbiome affect immunity and susceptibility to Mycobacterium Tuberculosis infection 2017 – present
Predicting emergence of bloodstream infections and GVHD in pediatric BMT populations: This project is a collaboration with Duke University and aims developing models to predict clinical outcome from microbiome dynamics and clinical covariates in a pediatric BMT patients’ cohort. 2018 – present